Synthesis and application of glycoconjugate-functionalized magnetic nanoparticles as potent anti-adhesion agents for reducing enterotoxigenic Escherichia coli infections.

نویسندگان

  • Yash S Raval
  • Roland Stone
  • Benjamin Fellows
  • Bin Qi
  • Guohui Huang
  • O Thompson Mefford
  • Tzuen-Rong J Tzeng
چکیده

Polyethylene oxide stabilized magnetic nanoparticles (PEO-MNPs) bio-functionalized with glycoconjugate (Neu5Ac(α2-3)Gal(β1-4)Glcβ-sp) (GM3-MNPs) are synthesized using click chemistry. Interaction of GM3-MNPs with Enterotoxigenic Escherichia coli (ETEC) strain K99 (EC K99) is investigated using different microscopic techniques. Our results suggest that GM3-MNPs can effectively act as non-antibiotic anti-adhesion agents for treating ETEC infections.

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عنوان ژورنال:
  • Nanoscale

دوره 7 18  شماره 

صفحات  -

تاریخ انتشار 2015